The Phenome-Exposome Atlas of Health and Disease Risk

Overview:

Non-genetic exposures comprising the exposome, including diet, lifestyle, infections and pollutants, may shape many clinical phenotypes relevant to health, yet evidence remains fragmented. We conducted an exposome-wide association study (ExWAS) across 619 indicators of exposure and 305 quantitative phenotypes across 10 independent US Centers for Disease Control and Preventional National Health and Nutrition Examination Survey (CDC NHANES) waves. Our findings highlight which exposures are most likely to add value to disease risk assessment, population surveillance, exposure prioritization, and next-generation longitudinal exposomics.

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Data and Software

Citation & Paper:

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